陳舜華 - 國立暨南國際大學護理系

陳舜華

專任副教授

電話：049-2910960 ext:(暫無分機)

E-mail：

教師研究室：

現職：國立暨南國際大學護理學系專任副教授

學歷：

長庚大學生物醫學研究所生理暨藥理學組博士
長庚大學基礎醫學研究所生理暨藥理學組碩士
長庚大學護理系學士

經歷：

輔英科技大學學士後護理系專任副教授
輔英科技大學學士後護理系專任助理教授
輔英科技大學護理系專任助理教授
輔英科技大學國際暨兩岸事務處國際專修部主任
長庚大學生物醫學工程研究所博士後研究員
林口長庚醫院婦癌研究中心博士後研究員
和信治癌中心醫院腫瘤內科病房護理師
台北醫學大學附設醫院腫瘤內科病房專科護理師
林口長庚醫院血液腫瘤科護理師

優良事蹟：

期刊客座編輯：Biomedicines、Life

學術專長：

生理學、藥理學、病理學、藥物開發、內外科護理學、腫瘤護理學及腫瘤轉譯醫學。

授課課程：

基礎醫學：生理學、藥理學、解剖學、病理學、基礎醫學應用。
護理學：內外科護理學、內外科護理學研討、專題報告寫作、OSCE、腫瘤護理學。
國考複習課：以基礎醫學為課程核心，系統性強化內外科護理學之國考複習課程。

A.研究成果：

代表著作

1. Chen SH, Chen PJ, Lee CH, Wu YP, Ahorsu DS, Griffiths M, Lin CY. Perceived stress mediating the association between mindfulness and resilience among registered nurses. Psychology Research and Behavior Management, 2023 Aug; 16:3035-3044 (SSCI; IF: 4.3; Rank: 29/147 Q1; Psychology, Multidisciplinary) 第一作者

主要著作

1.   Chen SH, Chen CH, Lin HC, Yeh SA, Hwang TL, Chen PJ. Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis. Journal of Advanced Research, 2024 Jul; online (IF: 11.4; Rank: 12/134 Q1, Multidisciplinary Sciences) 第一作者
2.   Zeng JS, Wu TY, Chen PJ, Chi WC, Chen NF, Wu YC, Fang LS, Chen SH*, Kuo LM, Sung PJ. Coniferains C and D, new eunicellin-based diterpenoids from Cladiella conifera. Heterocycles, 2022 Jun. 104(8), 1461 (SCI; IF: 0.6; Rank: 49/52 Q4, Chemistry, Organic) *通訊作者
3.   Lin CY, Alimoradi Z, Ehsani N, Ohayon MM, Chen SH*, Griffiths MD, Pakpour AH*. Suicidal ideation during COVID-19 pandemic among a large-scale Iranian sample: The roles of generalized trust, insomnia, and fear of COVID-19. Healthcare, 2022 Jan; 10:93 (SSCI; IF: 3.16; Rank: 35/88 Q2, Health Policy & Services) *通訊作者
4.   Pakpour AH, Lin CK, Safdari M, Lin CY, Chen SH*, Hamilton K*. Using an integrated social cognition model to explain green purchase behavior among adolescents. International Journal of Environmental Research and Public Health, 2021 Dec; 18:12633 (SSCI; IF: 4.614; Rank: 45/182 Q1, Public, Environmental & Occupational Health) *通訊作者
5.   Zeng JS#, Chen SH#, Lo YH, Chen NF, Wen ZH, Chen JJ, Liaw CC, and Sung PJ. A New Natural Butenolide, (5R)-3-tetradecyl-5-methyl-2(5H)-furanone, from Octocoral Cladiella Conifera. Heterocycles, 2021 Nov; 104. (SCI; IF: 0.6; Rank: 49/52 Q4, Chemistry, Organic) #共同第一作者
6.   Lin CY#, Chen SH#, Tsai CL, Tang YH, Wu KY, Chao A. Intracellular targeting of STIP1 inhibits human cancer cell line growth. Translational Cancer Research, 2021 Jan; 10(3):1313-1323. (SCI; IF: 1.24; Rank: 233/242 Q4, Oncology) #共同第一作者
7.   Chen SH, Chao A, Tsai CL, Sue SC, Lin CY, Lee YZ, Hung YL, Chao AS, Cheng AJ, Wang HS, Wang TH. Utilization of HEPES for enhancing protein transfection into mammalian cells. Molecular Therapy - Methods & Clinical Development, 2019 Jun; 13:99-111. (SCI; IF: 4.88; Rank: 24/136 Q1, Medicine, Research & Experimental) 第一作者

其他參考著作

1.   Chang YH, Lee YC, Chen SH, Fang SY, Cheng TP, Chi CH, Tsai KC, Chen PJ, Hung HY. Discovery of a novel C2-functionalized chromen-4-one scaffold for the development of p38α MAPK signaling inhibitors to mitigate neutrophilic inflammatory responses. Biochemical Pharmacology, 2025 May; 235: 116806. (IF: 5.3; Rank: 35/354 (9.9%), Pharmacology & Pharmacy)
2.   Chen PJ, Chen SH, Chen YL, Wang YH, Lin CY, Chen CH, Tsai YF, and Hwang TL. Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome. Journal of Advanced Research, 2024 Aug; 62:229-243. (IF: 11.4; Rank: 12/134 Q1, Multidisciplinary Sciences)
3.   el-Rahman YAA, Chen PJ, ElHady AK, Chen SH, Lin HC, El-Gamil DS, Aboushady Y, Abadi1 AH, Abdel-Halim M, Engel M. Development of 5-hydroxybenzothiophene derivatives as multi-kinase inhibitors with potential anti-cancer activity. Future Medicinal Chemistry, 2024 May; 16(12):1239-1254 (IF: 4.2; Rank: 21/60 Q2, Chemistry, Medicinal)
4.   Chen PJ, Tseng HH, Wang YH, Fang SY, Chen SH, Chen CH, Tsai SC, Chang YC, Tsai YF, and Hwang TL. Palbociclib blocks neutrophilic PI3K activity to alleviate psoriasiform dermatitis. British Journal of Pharmacology, 2023 Aug; 180(16):2172-88 (IF: 7.3; Rank: 25/277 Q1, Pharmacology & Pharmacy)
5.   Wagdy R, Chen PJ, Hamed MM, Darwish SS, Chen SH, Abadi AH, Abdel-Halim M, Hwang TL, and Engel M. From EGFR kinase inhibitors to anti-inflammatory drugs: Optimization and biological evaluation of (4-(phenylamino)quinazolinyl)-phenylthiourea derivatives as novel NF-κB inhibitors. Bioorganic Chemistry, 2022 Oct; 127, 105977. (IF: 5.1; Rank: 7/52 Q1, Chemistry, Organic)
6.   Tseng HJ, Kuo LM, Chen PJ, Chen SH, Liu CJ, Chien SY, Tsai YC, Wu YJ, Su TR, Sung PJ. Chlorofurancembranoids A and B: Novel cembranoids from octocoral Sinularia sp. Tetrahedron, 2022 Jul; 119, 132851. (SCI, IF: 2.1; Rank: 28/52 Q3, Chemistry, Organic)
7.   Darwish SS, Chen PJ, Hamed MM, Wagdy R, Chen SH, Abadi AH, Abdel-Halim M, Hwang TL, and Engel M. Development of (4-phenylamino)quinazoline alkylthiourea derivatives as novel NF-κB inhibitors. Pharmaceuticals, 2022 Jun; 15(7), 778. (IF: 4.6; Rank: 72/277 Q2, Pharmacology & Pharmacy)
8.   Zeng JS, Tseng CC, Tsai YC, Chen SH, Chen PJ, Chen NF, Wen ZH, Hwang TL, Sung PJ. Coniferains A and B, new eunicellin-based diterpenoids from the octocoral Cladiella conifera (Tixier-Durivault, 1943). Phytochemistry Letters, 2022 June; 49:88-92. (SCI, IF: 1.7; Rank: 143/238 Q2, Plant Sciences)
9.   Chao A, Liao ML, Chen SH, Lee YS, Tsai CN, Lin CY, Tsai CL. JAK2-mediated phosphorylation of stress-induced phosphoprotein-1 is critical for sustaining the JAK2/STAT3 signaling pathway in cancer cells. International Journal of Molecular Sciences, 2022 Feb; 23(5):2420 (SCI, IF: 5.6; Rank: 66/285 Q1, Biochemistry & Molecular Biology)
10.   Wang HS, Tsai CL, Chang PY, Chao A, Wu RC, Chen SH, Wang CJ, Yen CF, Lee YS, Wang TH. Positive associations between upregulated levels of stress-induced phosphoprotein 1 and matrix metalloproteinase-9 in endometriosis/adenomyosis. PLoS One, 2018 Jan; 13(1):e0190573. (SCI, IF: 3.7; Rank: 26/73 Q2, Multidisciplinary Sciences)
11.   Tsai CL, Chao A, Jung SM, Tsai CN, Lin CY, Chen SH, Sue SC, Wang TH, Wang HS, Lai CH. Stress-induced phosphoprotein-1 maintains the stability of JAK2 in cancer cells. Oncotarget, 2016 Aug; 7(31):50548-50563. (SCI, IF: 5.168; Rank: 44/217 Q1, Oncology)
12.   Chao A, Tsai CL, Jung SM, Chuang WC, Kao C, Hsu A, Chen SH, Lin CY, Lee YC, Lee YS, Wang TH, Wang HS, Lai CH. BAI1-Associated Protein 2-Like 1 (BAIAP2L1) Is a Potential Biomarker in Ovarian Cancer. PLoS One, 2015 Jul; 10(7):e0133081. (SCI, IF: 3.7; Rank: 26/73 Q2, Multidisciplinary Sciences)
13.   Wang TH, Chao A, Tsai CL, Chang CL, Chen SH, Lee YS, Chen JK, Lin YJ, Chang PY, Wang CJ, Chao AS, Chang SD, Chang TC, Lai CH, Wang HS. Stress-induced Phosphoprotein 1 as a secreted biomarker for human ovarian cancer promotes cancer cell proliferation. Molecular & Cellular Proteomics, 2010 May; 9(9):1873-84. (SCI, IF: 7.0; Rank: 5/77 Q1, Biochemical Research Methods)

B.專利:

1. Angel Chao, Tzu-Hao Wang, Shun-Hua Chen. Novel protein transfection compositions and uses thereof. Patent No.: 3360564; Date: 12.06.20 (European: Germany, UK, and France)
2. Tzu-Hao Wang, Shun-Hua Chen. Stress-induced phosphoprotein 1 as a biomarker for the detection of human ovarian cancers and endometriosis. Patent No.: US 7, 851,230B2; Date of Patent: Dec. 14, 2010.

C. 研討會論文:

1.   Chen PJ, Chen SH, Hung HY, and Lee YC. Discovery of a novel formyl peptide receptor 1 antagonist for treating neutrophilic inflammation. 第39屆生物醫學聯合學術年會, 2025
2.   Chen SH, Chen CH, Hsu CL, Chang YC, and Chen PJ. Natural bibenzyl exerts mitotic inhibition in the treatment of nasopharyngeal carcinoma. The 145th Annual Meeting of the Pharmaceutical Society of Japan, Fukuoka, Japan, 2025 (第一作者) (國際研討會)
3.   Chen SH, Chang YH, Kuan YH, Hwang TL, Hung HY, and Chen PJ*. Chromone-based derivatives act as novel antagonists of formyl peptide receptor 1 in the treatment of inflammatory neutrophilic oxidative stress. 第39屆天然藥物研討會, 2024 (第一作者)
4.   Tsai SC#, Chen SH#, Lam SH, Lee CH, Chen PJ. A selective ferroptosis inducer from Pholidota exerts anticancer ability in the treatment of colorectal cancer. 第38屆天然藥物研討會, 2023 (#共同第一作者)
5.   Chen PJ, Chen SH, and Hwang TL. Drug repurposing of ribociclib in the treatment of inflammatory disease. The 19th World Congress of Basic and Clinical Pharmacology, Glasgow, UK, 2023 (第一作者) (國際研討會)
6.   Chen SH, Chang YC, and Chen PJ. The ROS-dependent effects of Aaptos-derived natural components in the treatment of colorectal cancer. 第37屆生物醫學聯合學術年會, 2023 (第一作者)
7.   Chen PJ, Chen SH, Sie JY, and Hwang TL. The effects of a pure compound from Bletilla in the treatment of acute liver injury. 第37屆生物醫學聯合學術年會, 2023
8.   Tsai SC, Chen SH, Chen PJ, and Hwang TL. CDK inhibitor serves as a new drug for treatment of neutrophilic psoriasiform dermatitis. 第36屆生物醫學聯合學術年會, 2022 (永信李天德醫藥基金會壁報論文獎優等獎)
9.   Chen PJ, Chen SH, Tseng HH, and Hwang TL. CDK inhibitor ameliorates neutrophil-associated psoriasiform dermatitis by inhibiting PI3K activity. 第14屆亞太國際藥理學會議, 2021 (國際研討會)

D. 研究計畫:

年度	計畫名稱	擔任工作	起迄年月	補助機構	執行情形	經費總額
113	探討台灣白及天然物對大腸直腸癌與嗜中性白血球交互作用之影響及其療效評估 (113-2320-B-650-001-MY3)	共同主持人	2024/08/01 至2027/07/31	國科會	執行中	4,590,000
110	壓力誘導磷酸蛋白1調控卵巢癌免疫微環境之研究 (110-2314-B-242-003)	主持人	2021/08/01 至2022/07/31	國科會	已結案	900,000
114	探討肺炎克雷伯氏菌與第一甲醯化胜肽受體在N2嗜中性白血球的致病機轉 (EDCHP114002)	共同主持人	2025/02/01 至2026/01/31	義大醫院	執行中	350,000
114	從蘭科植物開發鐵依賴性死亡誘導劑用以治療大腸直腸癌之臨床前研究 (II) (EDCHP114008)	共同主持人	2025/02/01 至2026/01/31	義大醫院	執行中	250,000
114	台灣特有種植物-台灣油點草的抗發炎活性天然物研究 (EDAHP114034)	共同主持人	2025/02/01 至2026/01/31	義大醫院	執行中	200,000
113	從蘭科植物開發鐵依賴性死亡誘導劑用以治療大腸直腸癌之臨床前研究 (EDCHP113002)	共同主持人	2024/01/01 至2025/12/31	義大醫院	已結案	350,000
113	探討肺炎克雷伯氏菌引發嗜中性白血球N2極化作用的機制 (EDCHP113006)	共同主持人	2024/01/01 至2025/12/31	義大醫院	已結案	300,000
112	海洋海綿天然成份用於治療大腸直腸癌之臨床前研究 (EDCHP112011)	共同主持人	2023/01/01 至2023/12/31	義大醫院	已結案	168,000